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Select item 55862501.

Synthesis of a novel polycyclic ring scaffold with antimitotic properties via a selective domino Heck–Suzuki reaction

Esther Alza, Luca Laraia, Brett M. Ibbeson, Súil Collins, Warren R. J. D. Galloway, Jamie E. Stokes, Ashok R. Venkitaraman, David R. Spring

Chem Sci. 2015 Jan 1; 6(1): 390–396. Published online 2014 Sep 9. doi: 10.1039/c4sc02547d

PMCID:: PMC5586250

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Select item 80922812.

Two Distinct Conformations in 34 FliF Subunits Generate Three Different Symmetries within the Flagellar MS-Ring

Norihiro Takekawa, Akihiro Kawamoto, Mayuko Sakuma, Takayuki Kato, Seiji Kojima, Miki Kinoshita, Tohru Minamino, Keiichi Namba, Michio Homma, Katsumi Imada

mBio. 2021 Mar-Apr; 12(2): e03199-20. Published online 2021 Mar 2. doi: 10.1128/mBio.03199-20

PMCID:: PMC8092281

Article PDF–2.7M

Select item 30841243.

Diversity-oriented synthesis of macrocyclic peptidomimetics

Albert Isidro-Llobet, Tiffanie Murillo, Paula Bello, Agostino Cilibrizzi, James T. Hodgkinson, Warren R. J. D. Galloway, Andreas Bender, Martin Welch, David R. Spring

Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17): 6793–6798. Published online 2011 Mar 7. doi: 10.1073/pnas.1015267108

PMCID:: PMC3084124

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Select item 44412674.

A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds

Albert Isidro-Llobet, Kathy Hadje Georgiou, Warren R. J. D. Galloway, Elisa Giacomini, Mette R. Hansen, Gabriela Méndez-Abt, Yaw Sing Tan, Laura Carro, Hannah F. Sore, David R. Spring

Org Biomol Chem. 2015 Apr 21; 13(15): 4570–4580. Published online 2015 Mar 17. doi: 10.1039/c5ob00371g

PMCID:: PMC4441267

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Select item 84047045.

Assembly Mechanism of a Supramolecular MS-Ring Complex To Initiate Bacterial Flagellar Biogenesis in Vibrio Species

Hiroyuki Terashima, Keiichi Hirano, Yuna Inoue, Takaya Tokano, Akihiro Kawamoto, Takayuki Kato, Erika Yamaguchi, Keiichi Namba, Takayuki Uchihashi, Seiji Kojima, Michio Homma

J Bacteriol. 2020 Aug; 202(16): e00236-20. Prepublished online 2020 Jun 1. Published online 2020 Jul 27. doi: 10.1128/JB.00236-20

PMCID:: PMC8404704

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Select item 97501376.

A gating lever and molecular logic gate that couple voltage and calcium sensor activation to opening in BK potassium channels

Liang Sun, Frank T. Horrigan

Sci Adv. 2022 Dec; 8(50): eabq5772. Published online 2022 Dec 14. doi: 10.1126/sciadv.abq5772

PMCID:: PMC9750137

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Select item 86894127.

The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions

Bee Ha Gan, Josephine Gaynord, Sam M. Rowe, Tomas Deingruber, David R. Spring

Chem Soc Rev. 2021 Jul 5; 50(13): 7820–7880. Published online 2021 May 27. doi: 10.1039/d0cs00729c

Correction in:: Chem Soc Rev. 2022 Jan 24; 51(2): 792.

PMCID:: PMC8689412

Article

Select item 104507118.

Theoretical Advances in Polariton Chemistry and Molecular Cavity Quantum Electrodynamics

Arkajit Mandal, Michael A.D. Taylor, Braden M. Weight, Eric R. Koessler, Xinyang Li, Pengfei Huo

Chem Rev. 2023 Aug 23; 123(16): 9786–9879. Published online 2023 Aug 8. doi: 10.1021/acs.chemrev.2c00855

PMCID:: PMC10450711

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Select item 62738729.

Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers

Tze Han Sum, Tze Jing Sum, Warren R. J. D. Galloway, Súil Collins, David G. Twigg, Florian Hollfelder, David R. Spring

Molecules. 2016 Sep; 21(9): 1230. Published online 2016 Sep 16. doi: 10.3390/molecules21091230

PMCID:: PMC6273872

Article PDF–5.0M

Select item 682341510.

Dynamic modulation of modal coupling in microelectromechanical gyroscopic ring resonators

Xin Zhou, Chun Zhao, Dingbang Xiao, Jiangkun Sun, Guillermo Sobreviela, Dustin D. Gerrard, Yunhan Chen, Ian Flader, Thomas W. Kenny, Xuezhong Wu, Ashwin A. Seshia

Nat Commun. 2019; 10: 4980. Published online 2019 Oct 31. doi: 10.1038/s41467-019-12796-0

PMCID:: PMC6823415

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Select item 677428711.

Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment‐Based Drug Discovery

Thomas A. King, Hannah L. Stewart, Kim T. Mortensen, Andrew J. P. North, Hannah F. Sore, David R. Spring

European J Org Chem. 2019 Sep 1; 2019(31-32): 5219–5229. Published online 2019 Jul 29. doi: 10.1002/ejoc.201900847

PMCID:: PMC6774287

Article PDF–2.3M

Select item 656220412.

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

Paul Brear, Andrew North, Jessica Iegre, Kathy Hadje Georgiou, Alexandra Lubin, Laura Carro, William Green, Hannah F. Sore, Marko Hyvönen, David R. Spring

Bioorg Med Chem. 2018 Jul 15; 26(11): 3016–3020. doi: 10.1016/j.bmc.2018.05.011

PMCID:: PMC6562204

Article

Select item 601778713.

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions

Naomi S. Robertson, David R. Spring

Molecules. 2018 Apr; 23(4): 959. Published online 2018 Apr 19. doi: 10.3390/molecules23040959

PMCID:: PMC6017787

Article PDF–2.7M

Select item 533950914.

Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels

Guohui Zhang, Yanyan Geng, Yakang Jin, Jingyi Shi, Kelli McFarland, Karl L. Magleby, Lawrence Salkoff, Jianmin Cui

J Gen Physiol. 2017 Mar 6; 149(3): 373–387. doi: 10.1085/jgp.201611646

PMCID:: PMC5339509

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Select item 619803815.

Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections

Sarah L. Kidd, Thomas J. Osberger, Natalia Mateu, Hannah F. Sore, David R. Spring

Front Chem. 2018; 6: 460. Published online 2018 Oct 16. doi: 10.3389/fchem.2018.00460

PMCID:: PMC6198038

Article PDF–4.5M

Select item 911470416.

Insight Into Distinct Functional Roles of the Flagellar ATPase Complex for Flagellar Assembly in Salmonella

Tohru Minamino, Miki Kinoshita, Keiichi Namba

Front Microbiol. 2022; 13: 864178. Published online 2022 May 4. doi: 10.3389/fmicb.2022.864178

PMCID:: PMC9114704

Article PDF–7.3M

Select item 899103017.

Steady-state statistics, emergent patterns and intermittent energy transfer in a ring of oscillators

Tiemo Pedergnana, Nicolas Noiray

Nonlinear Dyn. 2022; 108(2): 1133–1163. Published online 2022 Feb 18. doi: 10.1007/s11071-022-07275-z

PMCID:: PMC8991030

Article PDF–3.9M

Select item 1067420618.

Design and Demonstration of a Microelectromechanical System Single-Ring Resonator with Inner Ring-Shaped Spring Supports for Inertial Sensors

Imran Khan, Ahmad Rahbar Ranji, Gnanesh Nagesh, David S.-K. Ting, Mohammed Jalal Ahamed

Sensors (Basel) 2023 Nov; 23(22): 9234. Published online 2023 Nov 16. doi: 10.3390/s23229234

PMCID:: PMC10674206

Article PDF–11M

Select item 558752719.

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066

Claudia De Fusco, Paul Brear, Jessica Iegre, Kathy Hadje Georgiou, Hannah F. Sore, Marko Hyvönen, David R. Spring

Bioorg Med Chem. 2017 Jul 1; 25(13): 3471–3482. doi: 10.1016/j.bmc.2017.04.037

PMCID:: PMC5587527

Article

Select item 634902620.

A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

Stephen J. Walsh, Soleilmane Omarjee, Warren R. J. D. Galloway, Terence T.-L. Kwan, Hannah F. Sore, Jeremy S. Parker, Marko Hyvönen, Jason S. Carroll, David R. Spring

Chem Sci. 2019 Jan 21; 10(3): 694–700. Published online 2018 Nov 9. doi: 10.1039/c8sc04645j